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Virtual Event

Jun 14, 2020 9:00 AM - Jun 18, 2020 5:00 PM

(Eastern Standard Time)

Fort Washington, PA 19034

DIA 2020 Global Annual Meeting

ON DEMAND - Replication of Randomized Controlled Trials Using Real World Data: What Does Good Look Like?

Session Chair(s)

David  Thompson, PhD

David Thompson, PhD

Founder and Principal Consultant

Rubidoux Research LLC, United States

This forum will explore issues in the use of real world evidence for regulatory purposes, focusing on attempts to replicate results from randomized controlled trials (RCTs) with analyses of real world data (RWD). It will describe two ongoing RCT replication efforts: the RCT DUPLICATE project and the OPERAND project. Issues related to the interpretation of findings will be highlighted and discussed.

Learning Objective : Discuss the key methodologic issues in using real world data (RWD) to replicate random controlled trials (RCTs); Assess discrepancies between findings from RCTs and real world studies; Evaluate the implications of current efforts to replicate RCTs using analyses of RWD sources.

Speaker(s)

David  Thompson, PhD

Replication of RCTs with RWE: What Does Good Look Like?

David Thompson, PhD

Rubidoux Research LLC, United States

Founder and Principal Consultant

Barbara E Bierer, MD

Replication of RCTs with RWE: the OPERAND Project

Barbara E Bierer, MD

Harvard Medical School, United States

Faculty Director, MRCT Center; Professor of Medicine

Lucinda  Orsini, MPH

Replication of RCTs with RWE: Moderator Setting the Stage

Lucinda Orsini, MPH

COMPASS Pathways, United States

Vice President - Value and Outcomes Research

William H. Crown, PhD, MA

Replication of RCTs with RWE: the RCT DUPLICATE Project

William H. Crown, PhD, MA

Brandeis University , United States

Distinguished Research Scientist, Heller School for Social Policy and Management

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