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DIA Global Center

2017年9月11日 (月) 午前 8:15 - 2017年9月12日 (火) 午後 3:30

21 Dupont Circle NW, Suite 300, Washington, DC 20036

Navigating Chemistry, Manufacturing, and Controls Through the Drug Development Process

Sessions 2, 3, and 4

Session Chair(s)

Albert S. Yehaskel, MBA

Albert S. Yehaskel, MBA

President and CEO

Refuah Global Pharmaceutical Development, Inc., United States

Session 2: Types of Submissions Affected by CMC

  • FDA Briefing Package
  • Investigational New Drug Application (IND)
  • Investigational Medicinal Product Dossier (IMPD)
  • New Drug Application (NDA/CTD)
  • Biologics License Application (BLA)
  • Common Technical Document (CTD)
  • Drug Master Files (DMFs)
  • Abbreviated New Drug Application (ANDA)
  • Amendments to an IND
  • Supplements to an Approved NDA/ANDA
  • IND/NDA Annual Reports
Session 3: Pre-formulation & Formulation Development
  • CMC Steps Leading to an IND
  • Key Active Pharmaceutical Ingredient (API) Characteristics
  • Development of Analytical Assay
  • Preformulation Testing
  • Solubility/Stability
  • Forced Degradation Studies
  • Formulation Development and Challenges
  • cGMP Manufacturing
  • Requisites for Clinical Trial Materials (CTM) Manufacture
  • Stability Testing and Storage
Session 4: FDA Briefing Process
  • The meeting package

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