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Session 3C: New Approaches in the Development of Immune Stimulatory Oligonucleotides in Oncology
Session Chair(s)
Arthur M. Krieg, MD
CEO and CSO
Checkmate Pharmaceuticals, United States
The innate immune system has evolved multiple different receptors for the detection of viral or bacterial RNA and DNA including several Toll-like receptors (TLR), the RIG-I family of helicases, cGAS, and others. These receptors trigger both T cell and B cell adaptive immune responses that are capable of killing infected host cells. Synthetic nucleic acids that activate several different innate immune receptors are in clinical development for the purpose of triggering innate immune resposnes against tumor antigens in subjects with cancer.
Learning Objective :
Speaker(s)
Session Co-Chair
Emily Place, PhD, MPH
Aclairo Pharmaceutical Development Group, United States
Senior Consultant
Making “Cold” Tumors “Hot” with Intratumoral Injections of a CpG-A Oligonucleotide Packaged in a VLP
Arthur M. Krieg, MD
Checkmate Pharmaceuticals, United States
CEO and CSO
Exploiting the TLR9 Pathway to Overcome Tumor Immune Ignorance
Jonathan Yingling
Idera, United States
Senior Vice President, Early Developement
Cancer Immunotherapy: Individualized mRNA-Based Vaccines for the Treatment of Cancer
Matthias Miller, PhD
BioNTech RNA Pharmaceuticals GmbH, Germany
Project Manager
Panel Discussion
All Session Speakers, United States