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Case Study 1 and 2
Session Chair(s)
Sandeep Menon, PhD
Chief Scientific Officer of Artificial Intelligence and Digital Science and SVP,
Pfizer Inc, United States
Case Study 1
An exploratory two-stage frequentist adaptive design (Maximizing design)
- Stage 1 is the Proof of Concept phase and Stage 2 the dose-finding phase
Case Study 2
An exploratory two-stage Bayesian adaptive design (NDLM design using SPCD approach)
- Adaptations are made at the end of Stage 1 and throughout Stage 2 based on a NDLM design with PoC and DF both based on a combined analysis of Treatment Periods 1 and 2 using a SPCD approach